PLE-2034

PLE-2034

A 40-year-old female was referred for hematologic evaluation because of findings of splenomegaly and a markedly elevated WBC count of 180,000/uL with the following differential count: Blasts 2%, Promyelocyte 15%, Metamyelocyte 20%, Myelocyte 10%, Bands 8%, Segmenters 30%, Lymphocytes 10%, and Basophils 5%. The hematologist made a primary diagnosis of CML. Which of the following treatment options for this case induces rapid disease control by lowering the WBC count?